The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing
By L. Deng, Chenzhen Du, Peiyang Song, Tianyi Chen, Shunli Rui, D. Armstrong, Wuquan Deng. Oxidative Medicine and Cellular Longevity, 2021
616 citations recorded by the source corpus.
Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.
Subfields: Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/90000336553c1b545c020c7d4a8f8e811860d625
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In Clinical Biochemistry
In Endocrinology, Diabetes and Metabolism
Citations in the corpus
- Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, positive): “376,377 Obesity is a metabolic disorder caused by genetic, environmental, and other factors, which is related to a variety of metabolic diseases, such as diabetes, hypertension, cardiovascular, and cerebrovascular diseases.”
- Diabetic Wound-Healing Science (2021, background): “Hyperglycemia can also lead to the production of reactive oxygen species (ROS) via the polyol, hexosamine, protein kinase C, and AGE pathways [18].”