Human DNA Repair Genes

By Richard D. Wood, M. Mitchell, J. Sgouros, Tomas Lindahl. Science, 2001

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The impact of a negligent G2/M checkpoint on genomic instability and cancer induction (2007, background): “DNA damage response mechanisms The DDR mechanisms encompass pathways of DNA repair, which are relatively lesion specific, as well as signal transduction pathways, which respond to either a DSB or a region of single stranded DNA (ssDNA”
Chromosome aberrations in solid tumors (2003, background): “More than 70 genes have been identified that have roles in DNA damage surveillance and repai”
Mechanisms of human DNA repair: an update. (2003, background): “Not all of them, however, have been characterised yet as to their function (Ronen and Glickman, 2001; Wood et al., 2001).”
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “The central components of the BER pathway include DNA glycosylases that recognize and remove specific types of damaged or mismatched DNA bases (Wood et al., 2005).”
Environmental and chemical carcinogenesis. (2004, background): “So far, over 130 DNA repair gene products have been identified [46].”
Oncotator: cancer variant annotation tool (2015, background): “Other cancer-specific resources utilized include the Cancer Gene Census (Futreal et al., 2004), ClinVar (Landrum et al., 2014), the Familial Cancer Database (http://www.familialcancerdatabase.nl/), and a curated set of DNA repair genes (Wood et al., 2005).”