Chromosome aberrations in solid tumors

By Donna Albertson, Colin C. Collins, F. McCormick, Joe W. Gray. Nature Genetics, 2003

859 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cf7272a9f11c6e7c84b5ae8311ed4cd2bf94ae51

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Genetics

In Molecular Biology

Citations in the corpus

Dissecting the metastatic cascade (2004, background): “The identification of the specific genetic and phenotypic changes that occur in disseminated tumour cells could also lead to new targets for antimetastatic therapie”
From polyploidy to aneuploidy, genome instability and cancer (2004, background): “The first surprising observation is that by the time many cancers become clinically apparent, their karyotypes are not that unstabl”
Absolute quantification of somatic DNA alterations in human cancer (2012, background): “…normal cells (tumor purity); (ii) the actual DNA content of the cancer cells (ploidy), resulting from gross numerical and structural chromosomal abnormalities, is unknown 9, 10, 11, 12, 13 and (iii) the cancer cell population may be heterogeneous, perhaps due to ongoing subclonal evolution 14, 15 .”
A Modified Bayes Information Criterion with Applications to the Analysis of Comparative Genomic Hybridization Data (2007, background): “The accurate identification of these regions is important for studying tumor progression and may also be useful in tumor classification (Albertson et al., 2003).”
Autophagy suppresses tumor progression by limiting chromosomal instability. (2007, background): “Gene amplification also leads to acentric, extrachromosomal fragments called double minutes, a common chromosomal aberration found in human solid tumors (Albertson et al. 2003).”
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. (2007, background): “Gene amplification is common in solid tumors (Albertson et al. 2003; Gebhart 2005; Albertson 2006) and is likely initiated by DNA double-strand breaks in cells lacking robust checkpoints (Chernova et al. 1998; Paulson et al. 1998).”
A statistical approach for array CGH data analysis (2005, background): “Gene dosage effect has become particularly important in the understanding of human solid tumor genesis and progression, and has also been associated with other diseases such as mental retardation [1,2].”
Analysis of array CGH data: from signal ratio to gain and loss of DNA regions (2004, background): “This mixture is then hybridized to the array CGH. Typical applications of arrays CGH are cancer studies since chromosome aberrations frequently occur during tumor progression (Albert-son et al., 2003) and human genetic disease research (Al-bertson and Pinkel, 2003; Shaw-Smith et al., 2004).”
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. (2006, background): “The evolution of a normal, finite-life-span somatic epithelial cell into an immortalized, metastatic cell requires deregulation of multiple cellular processes including genome stability, proliferation, apoptosis, motility, and angiogenesis (Albertson et al., 2003; Hanahan and Weinberg, 2000).”
Regularized Multivariate Regression for Identifying Master Predictors with Application to Integrative Genomics Study of Breast Cancer (2008, background): “It is widely agreed that variations in gene copy numbers play an important role in cancer development through altering the expression levels of cancer-related genes [Albertson et al. (2003)]. This is clear for cis-regulations, in which a gene’s DNA copy number alteration influences its own RNA trans”
Chromosome 21 and Down syndrome: from genomics to pathophysiology (2004, background): “Chromosomal instability of tumour cells, resulting in various trisomies and monosomies, is associated with tumour progressio”