The β-globin nuclear compartment in development and erythroid differentiation

By Robert-Jan Palstra, B. Tolhuis, Erik Splinter, R. Nijmeijer, Frank G. Grosveld, W. de Laat. Nature Genetics, 2003

387 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9889ee139221c423999862c6819f6bc7138b0a9c

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In Molecular Biology

Citations in the corpus

Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus (2004, background): “As recently described for globin, a set of distally positioned control elements, including the defined LCR, may interact to create a unique physical and regulatory environment that is favorable for high-level gene expression (37, 38).”
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “3C studies in mouse and human detected prominent interactions between these elements in globin-expressing cells, and these interactions were significantly less frequent in cells that do not express these genes: for example, cells in the brain 32,36 .”
The long-range interaction landscape of gene promoters (2012, background): “We identified additional known long-range interactions with DNase I hypersensitive sites (DHSs) near distal CTCF-bound elements (3 9 HS1 and HS-111) 2,13,14 .”
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. (2006, methodology): “The control library is generated by mixing equimolar amounts of minimally overlapping BAC clones covering the genomic region of interest (Palstra et al. 2003; Dekker 2006).”
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. (2007, neutral): “…in established I/11 erythroid progenitor cells that do not yet show activated (cid:1) -globin gene expression, contacts between the LCR and the genes are absent, but long-range DNA interactions already exist between the hypersensitive sites that contain CTCF-binding sites (Palstra et al. 2003).”
Beyond the sequence: cellular organization of genome function. (2007, positive): “Loop formation is not merely a consequence of transcriptional activation given that it occurs prior to gene activation when erythroid progenitor cells become lineage committed (Palstra et al., 2003).”