CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus.

By Erik Splinter, H. Heath, J. Kooren, Robert-Jan Palstra, P. Klous, Frank G. Grosveld, N. Galjart, W. de Laat. Genes & Development, 2007

743 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/9d6b95f429e45f94beca24fd16e0dc54498729ec

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Citations in the corpus

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. (2008, background): “A conditional deletion of CTCF has found no evidence of spreading of the repressive histone modifications into the beta-globin 3 HS1 locus (Splinter et al. 2006), suggesting an interaction of CTCF with another protein(s) that might play the role of barrier in the absence of CTCF.”
A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping (2014, result): “This is consistent with numerous reports, using a variety of experimental modalities, that suggest a role for CTCF and cohesin in mediating DNA loops (Splinter et al., 2006; Hou et al., 2008; Phillips and Corces, 2009).”
Cohesin loss eliminates all loop domains (2017, background): “…protein CTCF and the ring-shaped cohesin complex colocalize on chromatin (Wendt et al., 2008) and lie at the anchors of loops (Rao et al., 2014; Splinter et al., 2006) and the boundaries of contact domains (also called “topologically constrained domains”, “topologically associated domains”, or…”
CTCF: Master Weaver of the Genome (2009, positive): “Subsequent ChIP experiments confirmed direct CTCF binding to three sites upstream (5′HS85, 5′HS62/60, and 5′HS5) and one downstream (3′HS1) of the mouse β-globin locus (Bulger et al., 2003; Splinter et al., 2006).”
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization (2017, neutral): “Locus-specific studies have implicated the CTCF protein itself in mediating chromosome folding (Splinter, 2006).”
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017, positive): “CTCF proteins bound at enhancers and promoters can interact with one another and may thus facilitate enhancer-promoter interactions (Guo et al., 2015; Splinter et al., 2006), but CTCF does not generally occupy Cell.”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “An other example is CTCF (CCCTC-binding factor), which mediates long-range chromatin–chromatin interactions (due to looping) among others between distant regions of the β-globin locus in erythrocytes (Splinter et al., 2006), although the mechanistic basis of CTCF action remains obscure.”
CTCF Binding Polarity Determines Chromatin Looping. (2015, background): “We previously found no difference in b-globin gene expression in fetal livers carrying a CTCF binding site mutation in 30HS1 (Splinter et al., 2006).”