Ghrelin induces adiposity in rodents
By Matthias Tschöp, D. Smiley, M. Heiman. Nature, 2000
4,083 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/985777e31be95d5dfedffa559a1b88d42262ba68
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In Endocrine and Autonomic Systems
In Nutrition and Dietetics
In Physiology
Citations in the corpus
- The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, background): “…ghrelin on POMC somata may not be sufficient, however, to account for from the pituitary (Arvat et al., 2001). the potent orexigenic effects of ghrelin (Tschop et al., 2000, 2002; Nakazato et al., 2001; Wren et al., 2001a; Model of Ghrelin Action in the Brain The results outlined here provide both…”
- Ghrelin enhances appetite and increases food intake in humans. (2001, background): “In rodents ghrelin increases respiratory quotient, suggesting reduced fatty acid oxidation and increased glycolysis, which would favour fat deposition (6).”
- Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, background): “Central or peripheral administration of acylated ghrelin to rats acutely stimulates food intake and growth hormone release, and chronic administration causes weight gain (53).”
- Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. (2004, background): “(GH) release, energy balance, food intake, and long-term regulation of body weight in rodents (3, 4) and humans (5).”
- Ghrelin causes hyperphagia and obesity in rats. (2001, background): “Circulating ghrelin is elevated after a 48-h fast and subsequently lowered by 50% glucose administration into the stomach but not by the same volume of water (8).”
- Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “…cells located in other peripheral tissues, such as the intestines and pancreas (Kojima et al., 1999; Date et al., 2000, 2002; Hosoda et al., 2000; Tschop et al., 2000; Ariyasu et al., 2001; Horvath et al., 2001; Lee et al., 2002; Volante et al., 2002; Prado et al., 2004; Wierup et al., 2004;…”
- Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure (2002, background): “Orexigenic potency of the used bioactive ghrelin molecules did not differ from the potency of ghrelin that has been synthesized in our own laboratories (Tschop et al., 2000). des-m-Ghrelin was not bioactive, as expected based on earlier publications (Kojima et al., 1999).”
- Studies on the physiological functions of the melanocortin system. (2006, background): “Identified as an endogenous ligand for the GH secretagogue receptor (GHS-R) (93, 94), ghrelin is an acylated 28-amino-acid peptide predominantly secreted by the stomach, regulated by ingestion of nutrients (95–98) with potent effects on appetite (97, 98).”
- Deletion of Ghrelin Impairs neither Growth nor Appetite (2003, background): “Ghrelin administration is reported to increase fat deposition in rodents (35, 40).”