Ghrelin enhances appetite and increases food intake in humans.

By A. Wren, L. Seal, Mark A Cohen, A. Brynes, G. Frost, K. Murphy, W. Dhillo, M. Ghatei, S. Bloom. Journal of Clinical Endocrinology and Metabolism, 2001

2,565 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/4b78576df356fdd551f439877ff2bdbf88803eb6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Roger Cone
2. K. Kangawa
3. M. Kojima
4. Matthias Tschöp
5. P. Havel
6. Stephen R. Bloom
7. M. Heiman
8. Sigrid Breit

In Nutrition and Dietetics

1. Roger Cone
2. K. Kangawa
3. M. Kojima
4. Matthias Tschöp
5. Stephen R. Bloom
6. M. Heiman
7. P. Havel
8. D. Cummings

In Physiology

1. K. Kangawa
2. P. Havel
3. M. Kojima
4. Roger Cone
5. Matthias Tschöp
6. M. Heiman
7. N. Keim
8. Sharon S Elliott

Citations in the corpus

• Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, background): “In humans, intravenous infusion or subcutaneous injection increases both feelings of hunger and food intake, since ghrelin suppresses insulin release (56).”
• The Influence of Exercise on Cognitive Abilities (2013, neutral): “Central be of ghrelin given to human subjects increase appetite and energy intake (195).”
• Gut Hormones as Mediators of Appetite and Weight Loss After Roux-en-Y Gastric Bypass (2007, background): “Ghrelin produced from the stomach enhances hunger and food intake.(17) All these hormones have been shown to change after gastric bypass.”
• Ghrelin: structure and function. (2005, background): “Not only intracerebroventricular injection, but also intravenous and subcutaneous injection of ghrelin have been shown to increase food intake (173, 246, 265).”
• Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Prospective, Double Blind Study (2008, background): “Ghrelin injection stimulates food intake in rodents and humans via increased hypothalamic expression of the orexigenic neuropeptide Y.(10) Ghrelin has been proposed to have a role in meal initiation as the levels rise preprandially and fall proportionately in response to calorie ingestion.”
• Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (2008, neutral): “Peripheral administration of ghrelin to humans stimulates food intake (Wren et al., 2001; Small and Bloom, 2004).”
• Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. (2004, methodology): “Peak values of the active form of GLP-1, GLP-1(7-36), after meals did not differ between HFr and HGl days; however, GLP-1(7-36) levels remained elevated for a longer period (up to 120 min) after HFr than after HGl meals (Fig.”
• Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters (2006, background): “Ghrelin, a hormone produced from the stomach in the preprandial state, increases expression of the orexigenic hypothalamic neuropeptide Y (NPY) and stimulates food intake in rodents and humans.(17,18) In contrast, peptide YY (PYY), released postprandially from the distal gastrointestinal tract, acts”