Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.

By Luying Peng, Zhong-Rong Li, R. Green, I. Holzman, Jing Lin. Journal of NutriLife, 2009

1,849 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/98541d6aa321e498cd5579016a15cfc81c4b191f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. J. R. Kelly
6. E. Canfora
7. Lucy J. Mailing
8. F. Immerseel

In Neurology

1. Takuya Suzuki

In Nutrition and Dietetics

1. F. Immerseel
2. Albert K. Groen
3. L. Martin
4. Lan Lin
5. Takuya Suzuki
6. H. Holscher
7. R. Ducatelle
8. P. Guilloteau

Citations in the corpus

• The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology (2020, background): “SCFAs maintain gut health by promoting intestinal barrier integrity, mucus production, and supporting a tolerogenic response over inflammation (49, 50, 98, 99).”
• Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (2016, background): “…been proposed to explain these effects, the activation of signaling pathways mediated by protein kinases, such as AMP-activated protein kinase (Gao et al., 2009; Peng et al., 2009; Den Besten et al., 2015) or mitogen-activated protein kinases (MAPK; Jung et al., 2015), being a common observation.”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “Butyrate has also been shown to facilitate the association between transcription factors and the claudin-1 promoter (Wang et al., 2012a), increase AMP-activated protein kinase (AMPK) activity (Peng et al., 2009) and to reduce bacterial translocation (Lewis et al., 2010).”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Accumulating evidence has shown that butyrate could attenuate bacterial translocation across epithelia under metabolic stress [65], and enhance the gut barrier via augmenting tight junction assembly [66].”
• From the gut to the peripheral tissues: the multiple effects of butyrate (2010, positive): “In Caco-2 cells, a decrease in butyrate increasesintestinalpermeability (174) andbutyrateup-regulates lipoxygenase 5-LOX, 12-LOX and 15-LOX mRNA expression (175) .”
• Regulation of intestinal epithelial permeability by tight junctions (2012, background): “Butyric acid Decrease Caco-2 Promotion of occludin and ZO-1 assembly in Ca-induced TJ reassembly [205]”
• Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers (2018, background): “Butyrate in particular is important for maintaining health via regulation of the immune system (1), maintenance of the epithelial barrier (2, 3), and promotion of satiety following meals (4).”
• Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “butyrate could upregulate the tight junction and regulate epithelial permeability [55].”