Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells

By Sang‐Hun Lee, N. Lumelsky, L. Studer, J. Auerbach, R. McKay. Nature Biotechnology, 2000

1,329 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/982debee0c01940ab647c5361f91ce3967cfa074

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. G. Keller
2. Kenneth R. Boheler
3. A. Wobus
4. J. M. May
5. Austin G Smith
6. F. Harrison
7. K. Hochedlinger
8. E. Gould

In Molecular Biology

1. G. Keller
2. K. Hochedlinger
3. R. Jaenisch
4. Kenneth R. Boheler
5. A. Wobus
6. G. Daley
7. Austin G Smith
8. Qi-Long Ying

Citations in the corpus

• Origin and differentiation of microglia (2013, result): “In contrast to the numerous protocols for efficient generation of astrocytes and neurons from pluripotent stem cells (Lee et al., 2000; Zhang et al., 2001; Hu et al., 2010), there is little literature reporting methods for obtaining phenotypicallycorrect microglia from the same cell sources.”
• Stem Cell Organoid Engineering (2016, positive): “, 2013), midbrain dopaminergic neurons (Chambers et al., 2009; Lee et al., 2000; Perrier et al., 2004; Yan et al., 2005), and spinal cord motor neurons (Dimos et al.”
• Embryo-derived stem cells: of mice and men. (2001, background): “ES cell progeny can express appropriate markers and functional attributes not just of generic differentiation but of specific sub-types of neuron or cardiomyocyte, for example (Lee et al. 2000, Maltsev et al. 1993, Strubing et al. 1995).”
• Specification of motoneurons from human embryonic stem cells (2005, background): “, with subsequent differentiation into large projection neurons, such as midbrain dopaminergic neurons and spinal motoneurons, in response to specific sets of morphogen”
• Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury (2005, methodology): “Research of hESC differentiation benefits from two decades of mouse stem cell research, which has provided us with methods to differentiate mouse stem cells into several clinically relevant neural (Deacon et al., 1998; Brustle et al., 1999; Lee et al., 2000; Liu et al., 2000; Kim et al., 2003) and n”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, methodology): “Thereafter, neuronal cell differentiation can be supported by the addition of neuronal differentiation factors (22, 253) and maintained in vitro by neurotrophic differentiation (206) and survivalpromoting factors.”
• Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease (2008, methodology): “Following protocols developed for mouse ES cells, we treated FGF2 responsive, iPS cell-derived neural precursor cells with the regional patterning factors sonic hedgehog and FGF8 (23, 27).”