Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

By Vamsi K. Mootha, J. Bunkenborg, Jesper V. Olsen, Majbrit Hjerrild, Jacek R. Wisniewski, E. Stahl, Marjan S. Bolouri, H. N. Ray, S. Sihag, Michael Kamal and 3 more. Cell, 2003

908 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/9828d11137419585ad1d7c942fafc79b96ffe9b6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Matthias Mann
2. L. Galluzzi
3. Guido Kroemer
4. Shao-En Ong
5. Simone Fulda
6. Hanno Steen
7. D. Kelly
8. David E. Hill

In Spectroscopy

1. Matthias Mann
2. Shao-En Ong
3. Hanno Steen
4. Steven A. Carr
5. Vamsi K. Mootha
6. Jüergen Cox
7. Jesper V. Olsen
8. R. Aebersold

Citations in the corpus

• PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “Accordingly, it is not surprising that PGC-1α and PGC-1β are highly expressed in this organ (1, 3, 54).”
• Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007, background): “Interestingly, PGC-1a and mitochondrial OXPHOS targets are downregulated in human skeletal muscle of type II diabetic patients that might be linked to increased intra- myocellular triglyceride accumulation and insulin resistance (Mootha et al, 2003; Patti et al, 2003).”
• The abc's (and xyz's) of peptide sequencing (2004, methodology): “Integrative mRNA, proteomics and imaging techniques have also been applied to mammalian organelles, as was shown recently for mitochondri”
• Targeting mitochondria for cancer therapy (2010, background): “HSP90 is contained in mitochondria of cancer cells but not in their normal counterpart”
• A mitochondrial protein compendium elucidates complex I disease biology (2008, positive): “MitoCarta can also help elucidate the pathogenesis of common degenerative diseases, which have recently been associated with declining mitochondrial gene expression and rising reactive oxygen species production (Houstis et al., 2006; Mootha et al., 2003b; Schon and Manfredi, 2003).”
• Mitochondria: In Sickness and in Health (2012, background): “Advances in proteomic, genomic, and bioinformatic approaches have provided a comprehensive inventory of mitochondrial proteins in various eukaryotes (Gaston et al., 2009; Mootha et al., 2003; Pagliarini et al., 2008; Sickmann et al., 2003).”