Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

By Yifeng Zhang, M. Hoon, Jayaram Chandrashekar, K. L. Mueller, Boaz Cook, Di Wu, C. Zuker, N. Ryba. Cell, 2003

1,252 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/97f8dec2c4e7d2409844eb12ddcf9c3261be1688

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Nutrition and Dietetics

In Sensory Systems

Citations in the corpus

TRP Channels (2012, neutral): “Although mainly known as a plasma membrane channel, TRPM7 has also been shown on cholinergic synaptic vesicles, where it inﬂuences neurotransmitter release (203).”
Umami Taste Responses Are Mediated by α-Transducin and α-Gustducin (2004, background): “The downstream second messengers are probably cAMP and IP3, based on biochemical data (see above) and results from KO mice that show little or no response to umami compounds in the absence of Trpm5 or PLC 2 (Zhang et al., 2003; our unpublished results).”
Trp ion channels and temperature sensation. (2006, background): “TRPM5 is known to signal downstream of taste receptors and may contribute to the effects of temperature on taste (Cruz & Green 2000, Perez et al. 2002, Zhang et al. 2003).”
Common Sense about Taste: From Mammals to Insects (2009, background): “Indeed, subsequent behavioral studies demonstrated that rodents are unable to discriminate between bitter compounds (Spector and Kopka, 2002), and molecular studies showed that taste-blind animals engineered to restore bitter taste function under the control of single T2R promoters recovered taste r”
Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores (2010, background): “All tastes are detected and perceived via these taste receptors, which mediate signal cascades through second messenger molecules [45-49].”
Contribution of α-Gustducin to Taste-guided Licking Responses of Mice (2005, methodology): “First, others have reported dramatically attenuated lick responsiveness to sweeteners in mice with null mutations for T1R2, T1R3, T1R2+T1R3 and TRPM5, using the same testing procedure as described in experiment 5 (Zhang et al., 2003; Zhao et al., 2003).”
The receptors for mammalian sweet and umami taste. (2003, methodology): “(c), Taste preferences of control and T1R knockout animals were measured relative to water using a brief access taste test (Zhang et al., 2003).”
An introduction to TRP channels. (2006, background): “TRPM4 or TRPM5 currents also contribute to myogenic vasoconstriction of cerebral arteries (141), and TRPM5 is required for sweet, bitter, and umami taste transduction (142).”