The state of lipid rafts: from model membranes to cells.

By M. Edidin. Annual Review of Biophysics and Biomolecular Structure, 2003

1,323 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/97bacdd6e5acbd8598ba47393e78bd6d9db68bae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. G. Nicolson
2. I. Levitan
3. Raphael Zidovetzki
4. John Hancock
5. L. Pike
6. L. Rajendran
7. S. Mayor
8. K. Simons

In Molecular Biology

1. John Hancock
2. G. Nicolson
3. L. Pike
4. I. Levitan
5. Raphael Zidovetzki
6. K. Simons
7. G. Raposo
8. L. Rajendran

Citations in the corpus

• Lipid rafts: heterogeneity on the high seas. (2004, background): “28 Edidin, M. (2003) The state of lipid rafts: from model membranes to cells.”
• Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. (2003, background): “Lipid rafts have been associated with important biological processes such as endocytosis, adhesion, signaling, protein transport, apoptosis, and cytoskeleton organization (Deans et al., 2002; Edidin, 2003; Pike, 2003; Tsui-Pierchala et al., 2002).”
• Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. (2007, background): “Morphology, size, density and molecular composition of rafts in cellular membranes are still controversial, as summarized recently in several excellent reviews [33,35–47] and a detailed discussion of these topics is beyond the scope of the current review.”
• Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. (2004, background): “Model b: GPI-APs are distributed uniformly on theby observation of phase-segregated domains in artificial periphery of domains of radii R R0 l.membrane systems and from interpretations of DRM (B and C) Comparison of relative anisotropy profiles (A/A∞) versusstudies (Edidin, 2003).”
• SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function (2010, neutral): “…10.1113/jphysiol.2010.191585 raft are likely to exist based on differences in lipid and protein composition (Pike, 2004), but despite many years of study rafts in native membranes remain relatively controversial in terms of size, stability and physiological importance (Edidin, 2003; Munro, 2003).”
• Lipid rafts and membrane dynamics (2005, background): “Despite much evidence supporting the existence of raft domains, the size and the functions of these domains are debated (Edidin, 2003).”
• Exosomes: endosomal-derived vesicles shipping extracellular messages. (2004, background): “The recent description of the lipid composition of immuno-isolated B-cell exosomes by thin-layer chromatography revealed the enrichment of sphingomyelin, cholesterol and the glycolipid GM3 [16 ], lipids that are critical for the maintenance of rafts [29].”
• Lipid rafts: contentious only from simplistic standpoints (2006, background): “jpg" NDATA ITEM> ]> A widely accepted hypothesis in contemporary cell biology is that freely diffusing, stable, lateral assemblies of sphingolipids and cholesterol, which are termed lipid raft”
• The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. (2014, background): “plasma membrane lipid rafts to constitute functional, dynamic submicro- or nano-sized domains (b300 nm, most ~10–200 nm) that are characterized by the enrichments of cholesterol and sphingolipids [18,63,64,67–69,207–221].”