Mitochondrial retrograde signaling.

By Zhengchang Liu, Ronald A. Butow. Annual Review of Genetics, 2006

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Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “Nitrogen regulatory pathways assess these internal pools through sensing of ammonia, glutamate (Glu), and glutamine (Gln), main precursors for amino acid biosynthesis (Chen & Kaiser, 2002; Butow & Avadhani, 2004; Liu & Butow, 2006).”
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “TORC1 also regulates amino acid biosynthesis, in particular glutamine and glutamate homeostasis, via the retrograde response pathway (Komeili et al. 2000; Crespo and Hall 2002; Crespo et al. 2002; Liu and Butow 2006).”
Cancer as a metabolic disease (2010, background): “The RTG response evolved in yeast to maintain cell viability following periodic disruption of mitochondrial ATP production [110,114].”
Nutritional Control of Growth and Development in Yeast (2012, background): “The RTG regulatory pathway consists of four positive regulators—Rtg1, Rtg3, Rtg2, and Grr1 and four negative regulators—Mks1, Bmh1, Bmh2, and Lst8 (Liu and Butow 2006).”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “This phenomenon of retrograde signaling is well studied at the transcriptional level in the yeast Saccharomyces cerevisiae (130).”