Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.

By J. Ambati, B. Ambati, S. Yoo, S. Ianchulev, A. Adamis. Survey of ophthalmology, 2003

961 citations recorded by the source corpus.

Subfields: Molecular Biology, Ophthalmology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/966a19179595c3864062c4154d58b52e09b9a723

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. I. Bhutto
2. G. Lutty
3. O. Strauß

In Ophthalmology

1. I. Bhutto
2. G. Lutty
3. Yali Jia
4. Joachim Hornegger
5. O. Strauß
6. James G. Fujimoto

In Radiology, Nuclear Medicine and Imaging

1. Joachim Hornegger
2. O. Strauß
3. James G. Fujimoto

Citations in the corpus

• The retinal pigment epithelium in visual function. (2005, background): “The most severe complication in agerelated macular degeneration is the development of choroidal neovascularization (CNV) (20, 22, 99, 132, 183, 184).”
• An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice (2003, background): “But the pathology in human AMD, while pronounced in the macular area, is not confined to this central regio”
• Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye (2015, background): “Subsequent exudation and hemorrhage damage retinal tissue, resulting in vision loss (21).”
• Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors (2008, background): “Coupled with damage to Bruch’s membrane, this leads to proliferation of choroidal vessels, which invade the subretinal space [10].”
• Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration (2014, background): “Choroidal neovascularization can result in hemorrhage, fluid exudation, and fibrosis, resulting in photoreceptor damage and vision loss.(3) To diagnose neovascular AMD and evaluate the efficacy of treatment, determination of the presence and precise location of the CNV lesion is essential.”
• The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. (2005, neutral): “Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina, G J Anderson 1, W E Connor, J D Corliss, 1990 Jan;27(1):89-97. doi: 10.1203/00006450- 199001000-00023. https://pubmed.ncbi.nlm.nih.gov/2136947/ Essential fatty acids, DHA and human brain, Meharb”
• Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “There is a tendency for soft drusen to be confluent with each other and large confluent soft drusen are independent risk factors for AMD (Ambati et al., 2003).”