An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

By J. Ambati, A. Anand, S. Fernandez, E. Sakurai, B. Lynn, W. Kuziel, B. Rollins, B. Ambati. Nature Medicine, 2003

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International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “It has also been implicated in age-related macular degeneration in humans and in mouse models (Ambati et al., 2003; Combadiere et al., 2008; Raoul et al., 2010).”
Current concepts in the pathogenesis of age-related macular degeneration. (2004, background): “Nonetheless, an important benefit of identifying a gene that causes AMD (even if it were to account only for a small fraction of the total patient population) or a condition that very strongly resembles AMD or just a particular aspect of the disease is that one might then construct a biochemical pat”
The mouse retina as an angiogenesis model. (2010, background): “Although laser-induced CNV has been performed in various animal species,163–165 it is now most widely used in the mouse, and important insights into both the pathogenesis of choroidal neovascularization and the general angiogenic mechanisms have been gained from the mouse model of laser-induced CNV.”
Oxidative damage–induced inflammation initiates age-related macular degeneration (2008, background): “Similar sub-RPE debris is reported in mice subjected to dietary, lighting and/or genetic manipulation”