Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye
By Yali Jia, Steven T. Bailey, T. Hwang, Scott M Mcclintic, Simon S. Gao, M. Pennesi, C. Flaxel, A. Lauer, David J. Wilson, Joachim Hornegger and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2015
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Significance Retinal vascular diseases are a leading cause of blindness. Optical coherence tomography (OCT) has become the standard imaging modality for evaluating fluid accumulation in these diseases and for guiding treatment. However, fluorescein angiography (FA) is still required for initial evaluation of retinal ischemia and choroidal neovascularization, which are not visible in conventional structural OCT. The limitations of FA include poor penetration of fluorescence through blood and pigment, inability to determine the depth of the pathology due to its two-dimensional nature, and some uncommon but potentially severe complications. As a noninvasive three-dimensional alternative, OCT angiography may be used in routine screening and monitoring to provide new information for clinical diagnosis and management. Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.
Subfields: Ophthalmology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/3871413db5190befc19cb2d5e519f5ba67626253
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In Ophthalmology
Citations in the corpus
- Optical Coherence Tomography Angiography (2016, background): “In the choriocapillaris, assessing dropout would be important for AMD(65,91,92) and retinal degenerative diseases such as choroideremia.(65) Other approaches to assessing abnormal flow regions include characterization of the fractal dimension of vessel lines(104) and perfusion density mapping.”
- Optical coherence tomography angiography (2017, neutral): “38) (Ishibazawa et al., 2015; Jia et al., 2015; Matsunaga et al., 2015).”