Structure and function of Toll receptors and their ligands.

By N. Gay, M. Gangloff. Annual Review of Biochemistry, 2007

699 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9632ad5c28797faeb24b2649510d8a2914683061

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In Immunology

In Microbiology

Citations in the corpus

DAMPening Inflammation by Modulating TLR Signalling (2010, background): “A signalling competent conformation of the receptor is required for TLRs to function; however it is not known whether the conformation induced by DAMPs is similar or distinct to that produced by microbial structures where sequential changes in receptor conformation occur upon ligand binding (reviewe”
Plant immunity: towards an integrated view of plant–pathogen interactions (2010, result): “The expansion of these families is in contrast to the situation in animals, which possess 12 Toll-like receptors that fulfil an equivalent role to PRRs in plant”
Macrophage activation by endogenous danger signals (2008, background): “A portion of the cytoplasmic portion of TLRs was shown to have homology with the interleukin (IL)1 receptor family [25], and this domain was named the Toll/IL-1 receptor (TIR) domain.”
The role of oxidative stress during inflammatory processes (2013, background): “Upon ligand binding, TLR3 and TLR4 recruit the protein TIR domain-containing adaptor inducing interferon-β (TRIF) either directly for TLR3 or by the intermediate of TRIF-related adaptor molecule (TRAM) for TLR4 (Gay and Gangloff, 2007; Song and Lee, 2012).”
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (2007, neutral): “Toll-like receptors (TLRs), a family of type I transmembrane glycoproteins, are central to vertebrate innate immune responses (Gay and Gangloff, 2007; Medzhitov et al., 1997).”
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. (2009, background): “TLR family, partlybecause itcan dimerizewithTLR1orTLR6( Gay and Gangloff, 2007; Jin etal., 2007).Althoughextensive biochemical and structural research has been conducted for almost a decade, our understanding of TLR2-ligand interactions is still incomplete.”
The Role of TLR2 in Infection and Immunity (2012, methodology): “REVIEW ARTICLE published: 18 April 2012 doi: 10.3389/fimmu.2012.00079 The role ofTLR2 in infection and immunity”
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon (2009, background): “colonic epithelium expresses the toll-like receptor TLR4, which functions as a receptor for bacterial LPS (37).”