Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis

By J. Hove, R. Köster, Arian S. Forouhar, Gabriel Acevedo-Bolton, Scott E. Fraser, Morteza Gharib. Nature, 2003

1,083 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/961c036b4fc694d76c6d94138f81fbc133b9b5e3

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Citations in the corpus

Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons. (2004, background): “Because hemodynamic forces influence multiple aspects of myocardial formation (Hove et al., 2003; Sedmera et al., 1998, 1999; Taber et al., 1993), there are likely to be significant long-term effects of threering PAHs on this basis alone.”
Mechanical control of tissue and organ development (2010, background): “Finally, it is important to note that abnormal mechanical environments can interfere with normal organogenesis and produce organ malformations (Bartman et al., 2004; Cohen and Larson, 2006; Hove et al., 2003; Inanlou and Kablar, 2003; Lucitti et al., 2007; Moore et al., 2005; Vasilyev et al., 2009) ”
Mechanical control of stem cell differentiation (2008, background): “Disruption of hydrodynamic forces by the introduction of beads that block cardiac inflow or outflow produces dramatic cardiac defects in zebrafish, including failure of valve formation, and absence of heart looping and formation of a third chamber (Hove et al., 2003).”
Mechanotransduction in vascular physiology and atherogenesis (2009, background): “Altering shear can inhibit both the reorganization of the primitive vascular plexus into a properly organized vascular tree and the development of the outflow tract of the hear”
The developmental genetics of congenital heart disease (2008, background): “In zebrafish, altering haemodynamics mechanically or genetically has profound consequences on heart morpholog”
Microscale 3D flow mapping with μDDPIV (2007, methodology): “Hove et al. (2003) implemented micro-PIV to measure the velocity and shear stress fields of in vivo cardiovascular blood flow in embryonic Zebrafish.”
Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “Fluid shear forces are also likely to trigger or modulate transcription locally in the embryonic heart (Hove et al. 2003), but their connection to activation of NFAT has not been investigated.”
Mechanotransduction in development: a growing role for contractility (2009, background): “However, at the tissue level, the definition of external forces refers to forces that are developed outside of the system (for example, intracardiac fluid forces that are required for embryonic cardiogenesi”
Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014, background): “2C), areas predicted to experience strong fluid shear forces generated by blood flow (30, 31).”