The developmental genetics of congenital heart disease

By B. Bruneau. Nature, 2008

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How researchers see this paper

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Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage (2012, neutral): “Many of these genes have important roles in heart development and their dysregulation is associated with heart defects and cardiovascular disease (Bruneau, 2008; Srivastava, 2006).”
Epithelial-mesenchymal transitions: insights from development (2012, background): “Zeb1 and Zeb2 are also targeted by the miR-200 family (Christoffersen et al., 2007; Burk et al., 2008; Gregory et al., 2008; Korpal et al., 2008), which is regulated by the ratio of the levels of Akt1 to Akt2 (Iliopoulos et al., 2009).”
Braveheart, a long non-coding RNA required for cardiovascular lineage commitment (2013, background): “of gene expression patterns, and disruption of transcriptional networks that govern cardiac commitment underlies congenital heart disease (CHD) (Bruneau, 2008; Srivastava, 2006).”
Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “…Disease Misregulated development of the cardiovascular system is among the most common class of congenital birth defects and diseases of the cardiovascular system are among the most prevalent clinical issues for adult populations (Bruneau, 2008; Kathiresan and Srivastava, 2012; Roger et al., 2012).”
Pervasive roles of microRNAs in cardiovascular biology (2011, background): “16), the phosphatidylinositol-3-OH kinase (PI(3)K)–AKT pathway by miR-486 (ref.”