α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly

By Frauke Drees, S. Pokutta, Soichiro Yamada, W. Nelson, William I. Weis. 2005

922 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/95a81505a21318928fee7e56ed4ca0eaaccdf935

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Takeichi
2. Wenxiang Meng
3. Konrad Basler
4. G. Hausmann
5. T. Valenta
6. W. Nelson
7. Fa-Xing Yu
8. Karsten Kruse

In Immunology and Allergy

1. M. Takeichi
2. W. Nelson

In Molecular Biology

1. M. Takeichi
2. T. Valenta
3. Konrad Basler
4. G. Hausmann
5. Wenxiang Meng
6. W. Nelson
7. K. Jones
8. K. Willert

Citations in the corpus

• The many faces and functions of β‐catenin (2012, positive): “Importantly, the b -catenin-binding site on a -catenin overlaps with a - catenin’s homodimerization interface, hence a -catenin can bind to adherens junctions only in its monomeric state (resulting in an a -catenin/ b -catenin heterodimer) (Drees et al , 2005; Yamada et al , 2005).”
• Wnt signaling: is the party in the nucleus? (2006, background): “Although it had been assumed that the adhesion complexes are anchored to actin through -catenin, recent studies show that the -catenin:actin complexes interact only transiently, if at all, with the membrane-anchored E-cadherin junctional complexes (Drees et al. 2005; Yamada et al. 2005).”
• The ARP2/3 complex: an actin nucleator comes of age (2006, background): “, an effect that is reduced upon maturation of adhesion site”
• The many faces of actin: matching assembly factors with cellular structures (2007, background): “Interestingly, α-catenin binding to actin filaments also inhibits the Arp2/3 comple”
• Deconstructing the cadherin-catenin-actin complex. (2005, background): “Data presented in the accompanying paper (Drees et al., 2005) provide mechanistic evidence of why a-catenin does not bind simultaneously to the E-cadherin-b-catenin complex and actin filaments and new insights into how a-catenin may regulate actin dynamics at cell-cell contacts.”
• Adherens junction: molecular architecture and regulation. (2009, positive): “However, this concept was challenged by the finding that the a-catenin complexed with cadherin and b-catenin cannot bind F-actin in vitro and that only free a-catenins can do so (Drees et al. 2005; Yamada et al. 2005).”
• Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis (2007, background): “The role of actin dynamics and organization in adhesion has recently been re-emphasize”
• Nonequilibrium physics in biology (2019, background): “In addition, there is a feedback form the adhesion domains to the organization of the actin cytoskeleton (Drees et al., 2005).”