The ARP2/3 complex: an actin nucleator comes of age
By E. Goley, Matthew Welch. Nature reviews. Molecular cell biology, 2006
1,091 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Cell Biology
View Paper: https://www.semanticscholar.org/paper/e90f64b9a149b8e78af7b8fd1e0671f8222a81c6
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In Cardiology and Cardiovascular Medicine
In Cell Biology
Citations in the corpus
- Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “During the process of lamellipodia formation, the multiprotein complex Arp2/3 appears to be engaged in nucleation of branches, though the exact mechanism by which Arp2/3 causes filaments to branch is unknown.(53) In electron microscopy images, long, unbranched filaments are the dominating structures”
- The many faces of actin: matching assembly factors with cellular structures (2007, background): “The Arp2–Arp3 dimer thereby serves as a nucleation site, and the complex remains at the pointed end of the filamen”
- Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “F-actin filaments can be linked together through Arp2/3 proteins that form branches in the network at 70 deg angles from the original filament, which help the cell membrane protrude outward during cellular migration or spreading [37] [38].”
- UCSF Chimera, MODELLER, and IMP: an Integrated Modeling System (2011, background): “The actin-related protein-2/3 (ARP2/3), a seven-protein asymmetric complex, plays a major role in the formation of branched actin-filament networks during diverse processes ranging from cell motility to endocytosis (Goley and Welch, 2006).”
- Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “Similarly, actin-based motor proteins and the non-motor actin-related proteins (ARPs) [155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167] determine the overall architecture of the actin-based intracellular superstructures.”
- A Nucleator Arms Race: Cellular Control of Actin Assembly (2010, background): “b | ARP2/3 is recruited by the WCA domains of class I nucleation-promoting factors (NPFs) in proximity to cellular membranes (1).”