Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis

By Thomas Lecuit, P. Lenne. Nature reviews. Molecular cell biology, 2007

1,276 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Mechanical Engineering

View Paper: https://www.semanticscholar.org/paper/ed0d4534e250237a417be74638ec2605254b05db

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Citations in the corpus

Mechanical control of tissue and organ development (2010, background): “Intercellular surface tension results from a balance between adhesion forces generated by cadherin receptors and intracellular tension generated by the contractile actomyosin cytoskeleton (Lecuit and Lenne, 2007).”
Planar polarized actomyosin contractile flows control epithelial junction remodelling (2010, background): “Close inspection reveals two situations: (1) in most cases (88%, N 5 17), medial Myo-II pulses are followed by junctional pulses, and shrinkage steps proceed successfully without relaxation (14/15 cases, Fig.”
α-Catenin as a tension transducer that induces adherens junction development (2010, background): “In epithelial cell sheets, actomyosin forces are transmitted directly to adjacent cells through AJs associated with actin filament”
Adherens junction: molecular architecture and regulation. (2009, positive): “The observations of AJ remodeling during Drosophila germ band extension suggest that the AJs function not only as a physical ligand between cells but also as an active regulator for cell rearrangement (Lecuit and Lenne 2007).”
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis (2008, background): “To a large extent, these studies have emphasized the role of adhesion molecules and actomyosin cortical tension in cell shaping and tissue patternin”
Physics of adherent cells (2013, background): “Tensions that contract cell-cell junctions have emerged as a key factor that determines the dynamics of tissues (Aliee et al., 2012; Farhadifar et al., 2007; Lecuit and Lenne, 2007; Paluch and Heisenberg, 2009).”
MorphoGraphX: A platform for quantifying morphogenesis in 4D (2015, methodology): “This is not surprising since many key biological processes occur on surfaces, for example in epithelial layers ( Lecuit and Lenne, 2007 ; Savaldi-Goldstein et al., 2007 ; Heller et al., 2014 ).”
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner (2010, background): “…surface receptors integrate both chemical and mechanical cues to regulate biological processes as diverse as differentiation, vascular development, tumor growth, and malignancy (Bershadsky et al., 2003; Discher et al., 2005; Vogel and Sheetz, 2006; Lecuit and Lenne, 2007; Kumar and Weaver, 2009).”
Adherens junctions: from molecules to morphogenesis (2010, background): “These studies reveal how Rho activity can be inhibited, but how is it ultimately activated? Although Rho GEFs seem to activate Rho at cell junctions in certain circumstances (for example, during apical constrictio”