The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

By Brian J. North, Brett L Marshall, M. Borra, J. Denu, E. Verdin. Molecules and Cells, 2003

1,556 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/95a3888246d77ca0b44d3c4e7505300379e70e80

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. E. Seto
2. Xiang-Jiao Yang
3. L. Guarente
4. M. Haigis
5. Johan Auwerx
6. E. Verdin
7. F. Alt
8. Bor Luen Tang

In Geriatrics and Gerontology

1. L. Guarente
2. Johan Auwerx
3. E. Verdin
4. M. Haigis
5. E. Seto
6. C. Cantó
7. R. Houtkooper
8. Xiang-Jiao Yang

In Molecular Biology

1. L. Guarente
2. E. Verdin
3. E. Seto
4. M. Haigis
5. Johan Auwerx
6. Xiang-Jiao Yang
7. R. Mostoslavsky
8. R. Houtkooper

Citations in the corpus

• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “While in vitro deacetylase activity had not been found for SIRT6 (Liszt et al., 2005; Michishita et al., 2005; North et al., 2003), we detected low-level deacetylation of Pol b when incubated with purified SIRT6 (Figure S7A).”
• Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase (2004, background): “The physical in vivo association between SIRT1 and RelA/p65 implies that NF-kB may be a deacetylase target of Sirtuins.”
• The tubulin code: a navigation system for chromosomes during mitosis (2016, background): “Acetylation of lysine 40 of / [7_TD$DIFF]-tubulin occurs on the microtubule lumen and is mediated by the tubulin acetyl transferase /TAT1, whereas deacetylation is performed by at least two deacetylases, HDAC6 and Sirt2.”
• FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. (2004, neutral): “, 2002) and structural proteins like tubulin (North et al., 2003).”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “SIRT1, SIRT2, and SIRT3 have strong deacetylase activity (Imai et al., 2000; North et al., 2003; Schwer et al., 2002; Vaziri et al., 2001), while SIRT4, SIRT5, and SIRT6 are weak in comparison.”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, neutral): “1D; North et al. 2003).”
• PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation (2011, neutral): “The acetylation level of tubulin, a SIRT2 target (North et al., 2003), was not altered in muscle from PARP-1 / mice (Figure 2F).”
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (2006, background): “…September 8, 2006 ª2006 Elsevier Inc. SIRT4 Is a Mitochondrial ADP-Ribosyltransferase Mammalian homologs of SIR2 are localized to the nucleus (Liszt et al., 2005; Luo et al., 2001; Vaziri et al., 2001), cytosol (North et al., 2003), and mitochondria (Onyango et al., 2002; Schwer et al., 2002).”
• Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006, background): “SIRT7 localizes to the nucleolus of human cells (Michishita et al. 2005; Ford et al. 2006).”
• The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity (2012, neutral): “The human Sir2 ortholog, SIRT2, is an NAD +-dependent tubulin deacetylase.”