The tubulin code: a navigation system for chromosomes during mitosis
By M. Barišić, H. Maiato. 2016
65 citations recorded by the source corpus.
Before chromosomes segregate during mitosis in metazoans, they align at the cell equator by a process known as chromosome congression. This is in part mediated by the microtubule minus-end-directed kinetochore motor Dynein, which moves peripheral chromosomes to the poles along astral microtubules, and the plus-end-directed kinetochore motor CENP-E/Kinesin-7 that slides polar chromosomes along spindle microtubules towards the equator. Because different kinetochore motors move chromosomes in opposite directions along anisotropic spindle microtubules, a critical longstanding question has been how chromosomes are guided towards specific locations during mitosis. Here we discuss the exciting possibility that tubulin post-translational modifications, the so-called “tubulin code”, work as a navigation system for kinetochore-based chromosome motility along specific spindle microtubules, supporting congression to the cell equator.
Subfields: Cell Biology, Molecular Biology
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Citations in the corpus
- UniProt: the universal protein knowledgebase (2016, background): “Recent advances in the field suggest the existence of a tubulin code, similar to the histone code, with a combination of PTMs that are interpreted by reader proteins (11).”