The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
By A. Wren, C. Small, Helen L. Ward, K. Murphy, C. Dakin, Shahrad Taheri, A. Kennedy, G. Roberts, D. Morgan, M. Ghatei and 1 more. Endocrinology, 2000
1,631 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Physiology
View Paper: https://www.semanticscholar.org/paper/959cbaeb2845cee236cc52650211d462b435dcbf
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrine and Autonomic Systems
In Physiology
Citations in the corpus
- Ghrelin enhances appetite and increases food intake in humans. (2001, background): “Ghrelin b re ak fa st Ghrelin is the first circulating hormone shown to promote feeding and adiposity following systemic administration in experimental animals (5;6).”
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “is more potent than that of any other orexant (34).”
- Brain foods: the effects of nutrients on brain function (2008, neutral): “Peripheral administration of ghrelin increases food intake in normal rodent”
- The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, background): “Importantly, the weight gain and adipositySzent Istvan University Faculty of Veterinary Medicine caused by such positive energy balance is independentBudapest 1078 of ghrelińs ability to modulate GH secretion (Tschop etHungary al., 2000; Wren et al., 2000; Nakazato et al., 2001).”
- Ghrelin causes hyperphagia and obesity in rats. (2001, methodology): “Although acute systemic or ICV ghrelin administration causes potent stimulation of GH (16), significant stimulation of the growth axis (GH or IGF-1) was not detected after chronic administration.”
- Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. (2001, background): “In addition, it has been reported that intraperitoneal administration of ghrelin in freely feeding rats stimulated food intake (36).”
- Circulating ghrelin levels are decreased in human obesity. (2001, background): “Whereas the newly discovered gastric hormone ghrelin is undoubtedly a regulator of GH secretion (2), studies in rodents indicate that the peptide hormone also plays an important role in signaling hypothalamic centers regulating feeding and caloric state (1,4).”