Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats.

By J. Kamegai, H. Tamura, Takako Shimizu, S. Ishii, H. Sugihara, I. Wakabayashi. Diabetes, 2001

651 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/ac6a890f0dba30f8559dde92484f44550270595b

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In Endocrine and Autonomic Systems

In Nutrition and Dietetics

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Citations in the corpus

The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “Ghrelin stimulates the activity of neurones expressing NPY, AgRP and orexin (57,110,111).”
Ghrelin: structure and function. (2005, background): “The ARC is also a target of leptin, an appetite-suppressing hormone produced in adipose tissues, and NPY and AgRP, which are both appetite-stimulating peptides (76, 163).”
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, methodology): “Two of twenty mpPVH neurons we analyzed expressed TRH, on NPY and AGRP in affecting food intake (Nakazato et al., 2001; Tschop et al., 2002; Kamegai et al., 2001;and neither of these neurons appeared to be sensitive to ghrelin (30–100 nM) in relation to IPSC.”
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “One involves the NPY neurons (37, 362), and the other involves the melanocortin receptors and their agonistic and antagonistic ligands, the anorexigenic POMC-derived MSH and the orexigenic AGRP, which is expressed in NPY neurons (367).”
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (2008, positive): “Infusion of acylated ghrelin into the cerebral ventricles of rats markedly enhances food intake apparently through actions on the hypothalamus (Kamegai et al., 2001).”
Opposing Roles for NF-κB/Rel Factors p65 and c-Rel in the Modulation of Neuron Survival Elicited by Glutamate and Interleukin-1β* (2002, methodology): “Analysis was performed on protein extracts from hippocampus (1, 2) and cerebral cortex (3, 4) of mice treated with either saline (1, 3) or KA (2, 4) and killed 3 days after the treatment.”