Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.

By T. Powers, Peter Walter. 1999

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5. R. Loewith
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8. Howard Riezman

Citations in the corpus

• Mammalian Ceramide Synthases (2010, background): “LAC1 was then identified as a close homolog of LAG1, and a double deletion of the two genes resulted in lethality (13) or poor growth (14).”
• Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “TOR is indeed dedicated to controlling cell growth, but what is this target and how does it control cell growth?”
• Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. (2001, background): “TOR1/2 (target of rapamycin) encode two related phosphatidylinositol kinase homologues (Tor1p and Tor2p) which are part of a signal pathway that stimulates protein synthesis by the control of translation initiation [184] and of ribosome biogenesis by transcriptional activation [185,186] in response ”
• “Sleeping Beauty”: Quiescence in Saccharomyces cerevisiae (2004, background): “encoding components of the translational apparatus (120) and”
• Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. (2001, methodology): “A similar effect was observed for the ability of Lag1p or Lac1p to revert the growth defect of lag1 lac1 (Barz and Walter, 1999) and underlines the redundant functions of Lag1p and Lac1p.”
• The tor pathway: a target for cancer therapy (2004, background): “In yeast, the Tor signalling pathway controls protein turnover, transcription, actin cytoskeleton organization and represses autophag”
• Regulation of translation initiation by FRAP/mTOR. (2001, background): “…and elicits activation or repression of the same subset of genes modulated following a switch from a rich to a poor carbon or nitrogen source (Barbet et al. 1996; Schmidt et al. 1998; Powers and Walter 1999; Beck and Hall 1999; Cardenas et al. 1999; Hardwick et al. 1999; Shamji et al. 2000).”
• The mTOR Signalling Pathway in Human Cancer (2012, unknown): “starvation [103–105].”
• Revitalizing membrane rafts: new tools and insights (2010, background): “, and ER exit of GPI-anchored proteins depends on ceramide synthase”
• Upstream and downstream of mTOR. (2004, methodology): “Another potentially interesting mTOR candidate target is the large subunit (CBP80) of the nuclear cap-binding protein (nCBP; Wilson et al. 2000), which reportedly functions during the initial round of translation of each mRNA (Ishigaki et al. 2001). mTOR targets involved in transcription Consistent ”