The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
By A. Peled, O. Kollet, T. Ponomaryov, I. Petit, Suzanna Franitza, V. Grabovsky, Michal Magid Slav, A. Nagler, O. Lider, R. Alon and 2 more. Blood, 2000
812 citations recorded by the source corpus.
Subfields: Hematology, Immunology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/953763d9d33119ec28c3d4184ca1459620b99648
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In Immunology and Allergy
Citations in the corpus
- CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion (2003, background): “This pro-adhesive effect of SDF-1 is mediated by the activation of various adhesion molecules (e.g., integrins) on the surface of target cells rather than by increasing their de novo expression on the cell surface (Peled et al. 2000, Kijowski et al. 2001).”
- Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. (2000, background): “Activation of LFA-1, VLA-4, and VLA-5 on human CD34+ cells by SDF-1 is crucial for their engraftment in transplanted NOD/SCID (26).”
- Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. (2003, positive): “For example, CXCL12 has been shown to potently modulate the affinity state of both β1and β2-integrins on HPCs (17).”
- Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. (2002, background): “We demonstrated that SDF-1/CXCR4 interactions tightly regulate homing and repopulation of human SCID repopulating cells (SRC)/stem cells from BM, CB, and mobilized CD34 -enriched cells by chemotaxis and activation of the major integrins LFA-1, VLA-4, and VLA-5 under shear flow [51,70,71].”
- Hematopoietic stem-cell transplantation. (2006, background): “Cells expressing insufficient levels of CXCR4 detach and return to the bloodstream.(10) In humans, SDF-1 arrests CXCR4+ stem cells, facilitating extravasation through extracellular BM matrix barriers into the hematopoietic compartments.”