Hematopoietic stem-cell transplantation.
By M. Ende, F. I. Ende. New England Journal of Medicine, 2006
1,728 citations recorded by the source corpus.
Correspondence: Mark Tuthill Department of Medical Oncology, Hammersmith Hospital, imperial College National Health Service Trust, Ducane Rd, London, w12 0HS, UK Tel +44 208 383 1000 Fax +44 207 6039679 email marktuthill@doctors.org.uk Abstract: More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell “rescue.” Autologous HSCT is performed using the patient’s own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor–recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.
Subfields: Hematology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/3ee8f906c6364399f57300d497ee82c8ce44565d
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Citations in the corpus
- NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. (2010, background): “In addition, the morbidity, late effects, and financial costs associated with HSCT are substantial.(20) In contrast, NK cell therapy appears to be safe and relatively inexpensive treatment that will likely have few late effects.”
- The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. (2014, background): “The gastrointestinal tract is particularly impacted by alloHSCT, serving as both the origin and target of many posttransplant complications.(1) Under normal circumstances, the human gastrointestinal tract harbors a highly diverse population of microbes that, to a large degree, consists of obligate a”
- Hematopoietic stem-cell transplantation. (2006, background): “edu/pages/hematopoietic-stem-cell-transplantation [2] http://embryo.”