Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.

By J. Lévesque, Jean Hendy, Y. Takamatsu, P. Simmons, L. Bendall. Journal of Clinical Investigation, 2003

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Cancer and the chemokine network (2004, background): “Preclinical and clinical studies with stem-cell-mobilizing agents, such as granulocyte colony-stimulating factor and cyclophosphamide, cause a profound decrease in bone-marrow levels of CXCL12, owing to its degradation by neutrophil elastase, cathepsin G and MMP”
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “These are followed by degradation of SDF-1, increased expression of CXCR4 and mobilization of maturing leukocytes, progenitors and stem cell”
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, background): “Proteolytic cleavage associated with inactivation of SDF-1 was demonstrated by several degrading enzymes (28, 33, 34) including MMP-2 and MMP-9, which cleave the N-terminus (35).”