Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function.

By T. Ponomaryov, A. Peled, I. Petit, R. Taichman, L. Habler, J. Sandbank, F. Arenzana‐Seisdedos, Aude Magerus, A. Caruz, N. Fujii and 5 more. Journal of Clinical Investigation, 2000

607 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/8ce93f26fb4b556f8bd787f8d6b0b9e6e8c2b4de

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In Immunology

1. Robert Samstein
2. A. Kalinkovich

In Oncology

1. J. Talmadge
2. I. J. Fidler
3. S. Fricker
4. B. Teicher

Citations in the corpus

• The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “SDF-1 is upregulated in damaged tissues, such as the liver [9], arteries [10] or irradiated BM [11] (Table 1).”
• HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, background): “These interactions mimic those observed between HSCs and the SDF-1–rich BM endosteum region in which hematopoietic progenitors are localized in close proximity to this chemokine (32, 36, 37), which is also a survival factor for both human and murine progenitors (38, 39).”
• Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “The chemokine SDF-1 is highly expressed by endosteal osteoblasts and bone marrow endothelial cell”
• Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. (2003, positive): “CXCL12 is produced by the BM stroma and bone tissue as two isoforms, α and β, which differ by a four-residue extension at the C-terminus in the β isoform, and it is thought to form a decreasing gradient from the extravascular compartment of the BM toward the lumen of vessels irrigating this tissue (”
• Bone-marrow haematopoietic-stem-cell niches (2006, background): “4 ), which is expressed by several types of bone-marrow stromal cell, including osteoblasts and vascular endothelial cell”