NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

By M. Wlodarska, Christoph A. Thaiss, Roni Nowarski, Jorge Henao-Mejia, Jian-ping Zhang, E. Brown, G. Frankel, M. Levy, Meirav N. Katz, W. Philbrick and 3 more. Cell, 2014

660 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9511332857dd73bcef82dc5e46fd0394f9563f46

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Citations in the corpus

Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review (2023, background): “Different studies discovered that the inactivation of an inflammasome’s component, NOD-like receptor family pyrin domain–containing 6 (NLRP6) protein, in mice, determines the expansion of Prevotella spp. and TM7 bacteria [29].”
Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “SCFA might activate NALP6 through the GPCR pathway, further promoting gut goblet cells to secret mucus, which is an important barrier to separate the bacteria and epithelial cells [53, 54].”
Mechanisms and consequences of intestinal dysbiosis (2017, background): “The higher susceptibility is enhanced by impaired mucus secretion from goblet cells in NLRP6-deficient mice leading to a reduced mucus layer [123].”
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. (2016, positive): “The spatial segregation between the epithelial layer and commensal bacteria is maintained by the production of mucus and antimicrobial peptides (Hooper et al., 2012; Johansson et al., 2008; Vaishnava et al., 2011; Wlodarska et al., 2014).”
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. (2017, background): “Intestinal mucin is mainly composed of a single highly O-glycosylated protein called mucin 2 (MUC2), which is produced by goblet cells and secreted into the intestinal lumen in a TLR- and NLRP6-dependent manner (Birchenough et al., 2016; Johansson et al., 2008; Wlodarska et al., 2014).”
New developments in goblet cell mucus secretion and function (2015, positive): “Lack of NLRP6 was previously shown to have functional consequences in vivo as knockout mice were more susceptible to both DSS and Citrobacter rodentium-induced colitis (41;44).”
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, positive): “This role for caspase-8 in mediating inflammasome activation is supported by another study in which caspase-8 inhibition reduced NLRP3 and AIM2-induced caspase-1 activation (Wu et al., 2014).”
Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling (2015, background): “…expressed in intestinal epithelial cells, including goblet cells (Elinav et al., 2011; Gremel et al., 2015; Wlodarska et al., 2014), where it was found to be essential for mucosal self-renewal, proliferation, and mucus secretion (Chen et al., 2011; Normand et al., 2011; Wlodarska et al., 2014).”
Regulation of inflammasome activation (2015, background): “NLRP6 is required for host protection against DSS-induced colitis and Citrobacter infection (202, 203).”