The Biogenesis, Functions, and Challenges of Circular RNAs.

By Li Yang, Ling-Ling Chen. Molecules and Cells, 2018

1,764 citations recorded by the source corpus.

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. Recent studies have shown that their biogenesis requires spliceosomal machinery and can be modulated by both cis complementary sequences and protein factors. The functions of most circRNAs remain largely unexplored, but known functions include sequestration of microRNAs or proteins, modulation of transcription and interference with splicing, and even translation to produce polypeptides. However, challenges exist at multiple levels to understanding of the regulation of circRNAs because of their circular conformation and sequence overlap with linear mRNA counterparts. In this review, we survey the recent progress on circRNA biogenesis and function and discuss technical obstacles in circRNA studies.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f6f8dafae294c55edbe5d45c8a307faccc2b320

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Liang Chen
2. Changliang Wang
3. Huiyan Sun
4. Juexin Wang
5. Yanchun Liang
6. Yan Wang
7. Garry Wong
8. Sarra Setrerrahmane

Citations in the corpus

• Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. (2019, neutral): “Given that circRNAs contain sequences almost entirely identical to those of their linear cognate RNAs, challenges exist at multiple levels to understand their regulation and functions (Li et al., 2018).”
• The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “While this review focuses on circRNA-related bioinformatics tools, other recent reviews provide perspectives on understanding the functions of circRNA with evidence gathered from regulation in tissues and subcellular locations, biogenesis, degradation, translation, transport, interactions and evolut”
• Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Contrary to conventional linear RNA, circRNAs are noncoding RNAs that generated from precursor mRNAs by back-splicing circularization, which is derived from exonic circRNAs, intronic circRNAs, exonic-intronic circRNAs and ntergenic circRNAs.(269) CircRNAs can affect gene transcription, splicing and ”