Past, present, and future of circRNAs
By I. Patop, Stas Wüst, Sebastian Kadener. EMBO Journal, 2019
1,012 citations recorded by the source corpus.
Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e09587ddc46517f7cc8c7b3f78ac363d8b4ef54d
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Citations in the corpus
- The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “While this review focuses on circRNA-related bioinformatics tools, other recent reviews provide perspectives on understanding the functions of circRNA with evidence gathered from regulation in tissues and subcellular locations, biogenesis, degradation, translation, transport, interactions and evolut”
- Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “Numerous circRNAs exhibit specificity to certain tissues and developmental periods [5, 31, 32].”