Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd.

By M. Zylka, F. Rice, David J. Anderson. Neuron, 2005

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Mechanisms of sensory transduction in the skin (2007, background): “First, localization studies involving genetically labelled neuronal subpopulations have revealed at least two populations of sensory afferent fibres that ramify within distinct epidermal layer”
Trp ion channels and temperature sensation. (2006, background): “Experiments by Zylka et al. (2005) using genetically coded axonal tracers have revealed that peptidergic and nonpeptidergic epidermal innervations of sensory neurons are spatially segregated within the skin and also in the spinal cord.”
Nociceptors: the sensors of the pain pathway. (2010, background): “main axon and terminate in the wall of arterioles and surrounding connective tissue, and may innervate distinct regions in the dermis and epidermis (17, 30).”
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, methodology): “However, IB4-saporin targets a carbohydrate epitope present on multiple cell types, whereas Mrgprd is exclusively expressed in unmyelinated afferents (2, 14).”
Neuronal circuitry for pain processing in the dorsal horn (2010, background): “Expression of Mas-related G-protein coupled receptor member D (MRGPRD), a sensory neuron-specific G protein-coupled receptor, has recently been shown to define a population of non-peptidergic nociceptive C fibres in the mous”