Neuronal circuitry for pain processing in the dorsal horn
By A. Todd. Nature Reviews Neuroscience, 2010
1,356 citations recorded by the source corpus.
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.
Subfields: Pediatrics, Perinatology and Child Health, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/2abdbdcfeda3a83a525d4fd4e5b0bb9365dacd7d
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Citations in the corpus
- Discriminative and affective touch: sensing and feeling. (2014, background): “The superficial dorsal horn (laminae I/II) has been considered largely nociceptive in function (Todd, 2010).”
- The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Modulatory control of acute pain is provided by descending inhibitory and facilitatory pathways from the brain and from inhibitory and excitatory interneurons within the spinal cord (Todd 2010; D’Mello and Dickenson 2008).”