Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
By T. Haas, Christoph H. Emmerich, Björn Gerlach, Anna C. Schmukle, Stefanie M. Cordier, E. Rieser, R. Feltham, J. Vince, U. Warnken, T. Wenger and 4 more. Molecules and Cells, 2009
792 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/943d02b810af4e6c6b16834b673332605c3fb37b
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Citations in the corpus
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, neutral): “[86–90].”
- Post-translational modifications in signal integration (2010, background): “Furthermore, the LUBAC complex is known to exist in and stabilize the TNFR signaling complex in a TRADD-, TRAF2- and cIAP2-dependent manne”
- Molecular Basis of NF-κB Signaling (2013, background): “The CC region of the TRAF2 trimer recruits cIAP1/2 (5, 7, 31, 34, 35, 70, 78, 115, 134) and the RING domains of cIAP1/2 nucleate polyubiquitination of target proteins, including RIP1 kinase, NIK, TRAF2, and cIAP1/2 (5, 7, 16, 30, 31, 34, 35, 69, 77, 95, 96, 119, 133).”
- Signaling in innate immunity and inflammation. (2012, background): “Recruitment of LUBAC components sharpin, HOIL-1, and HOIP to the TNF-RI complex is linked to cIAP ubiquitin ligase activity, and linear ubiquitylation of RIP1 and NEMO may stabilize the TNF-RI signaling complex (Haas et al. 2009; Gerlach et al. 2011; Ikeda et al. 2011; Tokunaga et al. 2011).”
- The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics (2021, background): “This signaling pathway results in the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs) [14,15].”
- Regulation of NF-κB by TNF Family Cytokines (2014, background): “Analyses by multiple groups have shown that this modified RIP1 is ubiquitinated either through K63 (lysine-63) [74, 75, 78, 79] or linear [77] ubiquitin linkages.”