The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

By Simone Brabletz, Thomas Brabletz. EMBO Reports, 2010

824 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/943882928e335101ae3d5bb47443b8a3543f4e1d

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Citations in the corpus

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “In many carcinomas, these signals converge on a core EMT regulatory network, also referred to as “motor of cellular plastic-ity” owing to its coupling with many key cellular properties such as apoptosis, cell cycle, metabolism, and immunosuppression (21–25).”
The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “Members of the miR-200 family play an important role in regulating the epithelial phenotype by targeting Zeb factors, thereby preventing E-cadherin downregulation and the EMT (Brabletz & Brabletz 2010).”
The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective (2019, background): “It has been evaluated that the miR‐200 expression has the capacity to reverse resistance to EGFR inhibitor therapy in bladder cancer cells (Adam et al., 2009; Bojmar et al., 2013; Brabletz & Brabletz, 2010; Hill, Browne, & Tulchinsky, 2013; Wang et al., 2014).”
Epithelial-mesenchymal transitions: insights from development (2012, background): “Peinado et al., 2007 Twist Contains a basic helix-loop-helix motif that interacts with Bmi1, together with the PRC2 complex to repress E-cadherin and p16INK4a through chromatin remodeling.”
Anoikis: an emerging hallmark in health and diseases (2012, background): “Actually, ZEB factors and miR200 reciprocally control their expression in a strict feedback loop [133].”
Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “Of note, the described microRNAs target not only EMT-TFs themselves, but also genes like BMI1 , CD44 , CD133 , JAG1 , or MYC that are involved in tumor-relevant “non-classical” EMT functions like stemness and survival as discussed below (Brabletz & Brabletz, 2010; Brabletz et al , 2011).”
Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “…of the Zeb family form a double-negative feedback loop with the miR-200 family of microRNAs, causing this regulatory loop to operate as a bi-stable switch between the epithelial and mesenchymal state in a variety of carcinomas (Brabletz and Brabletz, 2010; Burk et al., 2008; Hill et al., 2013).”