Negative regulation of cytokine signaling pathways.

By H. Yasukawa, Atsuo T. Sasaki, A. Yoshimura. Annual Review of Immunology, 2000

650 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/941781d7e1e65262e1991925abfe2ec43267223b

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Citations in the corpus

Oncogenic kinase signalling (2001, background): “This occurs through SOCS-induced protein degradation, and, for SOCS-1 and -3, through binding of the N-terminal region to the activation loop of JAK kinas”
Toll-like receptors in innate immunity. (2004, positive): “SOCS1 is a member of the SOCS family of proteins that are induced by cytokines and that negatively regulate cytokine signaling pathways (111).”
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms (2004, background): “SOCS-1 and SOCS-3 have been shown to bind JAK tyrosine kinase and attenuate its ability to phosphorylate signal transducer and activator of transcription (STAT) proteins (34, 55), while CIS and SOCS-3 bind phosphorylated cytokine receptors and competitively interfere with binding of other src homolo”
Suppressors of cytokine signaling and immunity (2003, background): “Several members of the SOCS and cytokine-inducible SH2 protein (CIS) family of intracellular proteins regulate the responses of immune cells to cytokine”
Regulation of cytokine signaling and inflammation. (2002, background): “[54] Yasukawa H, Sasaki A, Yoshimura A.”
Toll-like receptor signalling (2004, background): “SOCS1 is a member of the SOCS family of proteins, which are induced by cytokines and negatively regulate cytokine-signalling pathway”
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways (2007, background): “The T H 1 differentiation pathway may also be favored in these circumstances by a decrease in SOCS3, an inhibitor of Janus kinase–STAT signaling that is a key target of IL-6 receptor signalin”
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003, background): “Several members of the SOCS (also known as cytokine-inducible Src homology domain 2 (SH2) protein, CIS) family of proteins, which are implicated in the negative regulation of various cytokines, have been clone”