Suppressors of cytokine signaling and immunity

By Masato Kubo, Toshikatsu Hanada, A. Yoshimura. Nature Immunology, 2003

667 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/54556b8edd64cbff5610f203a6a61c05188754e0

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Citations in the corpus

SOCS proteins, cytokine signalling and immune regulation (2007, background): “However, they are also induced by various other stimuli, such as lipopolysaccharide (LPS), isoproterenol, statins and cyclic AMP (cAMP), and SOCS1 expression in immature thymocytes is developmentally regulated in the absence of cytokine signallin”
STATs in cancer inflammation and immunity: a leading role for STAT3 (2009, neutral): “Recent evidence points to a role for STAT3 in mediating the cancer-promoting properties, such as angiogenesis, of tumour-associated MDSCs and macrophage”
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses (2010, positive): “Although SOCS1 also controls other signaling pathways, loss of SOCS1-dependent negative regulation of Stat1 is the major contributor to the IFNg-mediated immunopathology in mice with SOCS1 deficiency (Kubo et al., 2003; Alexander et al., 1999; Horino et al., 2008; Marine et al., 1999).”
The interferon response circuit: Induction and suppression by pathogenic viruses (2005, neutral): “The suppressor of cytokine signaling (SOCS) proteins prevent STAT activation (Kubo et al., 2003) whereas protein inhibitor of activated STAT (PIAS) family members function as small ubiquitin-like modifier (SUMO) E3 ligases and inhibit the transcriptional activity of STATs (Shuai and Liu, 2005) .”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “Functional interaction or antagonism between NF-κB and STAT3 can also occur at the level of signal transduction regulators, such as SOCS proteins whose expression is controlled by both NF-κB and STAT3 (42,67,68).”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “SOCS3 is induced by STAT3 and considered to regulate a major negative feedback loop of a gp130-mediated signaling pathway (118–120).”
Seeded Bayesian Networks: Constructing genetic networks from microarray data (2008, background): “The up-regulation of SOCS3 represents a classical negative feedback loop required to regulate the magnitude and duration of signalling downstream of the IFNG receptor signalling, in addition to limiting the response to any subsequent cytokine stimulus [29,30].”
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury (2006, background): “Socs3 is the negative feedback molecule of Stat3 and the 'bipolar' relationship between Stat3 and Socs3 has been noted in several selective deletion experiment”