YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
By L. Azzolin, T. Panciera, Sandra M. Soligo, E. Enzo, S. Bicciato, S. Dupont, S. Bresolin, C. Frasson, G. Basso, V. Guzzardo and 3 more. Cell, 2014
1,070 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/93e487db3559457c54021763710b27bb0728371b
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Citations in the corpus
- YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration (2018, methodology): “This is similar to the reported requirement for YAP/TAZ during tumor formation upon the loss of Apc (Azzolin et al., 2014).”
- Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “These results are dissimilar with previous reports that show Wnt3a-induced YAP/TAZ and b-catenin activation share a commonmechanism and function via interaction with the destruction complex, which was independent of the Hippo pathway (Azzolin et al., 2012, 2014).”
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “YAP/TAZ have been shown to be components of the destruction complex and are regulated byWnt in a fashion similar to that of b-catenin (Azzolin et al., 2012, 2014).”
- Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “As a consequence, the complex becomes saturated by the phosphorylated form of b-catenin, leading to accumulation of newly synthesized b-catenin, free to translocate to the nucleus and to activate target genes (Li et al., 2012; Azzolin et al., 2014).”
- The Hippo Signaling Pathway in Development and Disease (2019, background): “In mouse intestines, YAP/TAZ are highly expressed at the base of the crypts, and their inactivation has no discernable effects on normal development but severely compromises regeneration upon intestinal injury (Azzolin et al., 2014; Cai et al., 2010).”
- The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Under Wnt ON conditions, YAP/TAZ is dissociated from Axin1 and accumulates in the nucleus to regulate the Wnt/β-catenin signaling pathway.(329) In addition to the Ub ligases reported above, the K48 linkage polyubiquitination mediated by Nedd4 also functions as a proteolytic signal and degrades WW45 ”
- The Hippo signalling pathway and its implications in human health and diseases (2022, background): “195,198 In the liver, Yap1 activation in hepatocytes contributes to liver regeneration.”
- YAP/TAZ at the roots of cancer (2016, background): “Recent studies found that, in the absence of Wnt stimulation, cytoplasmic YAP/TAZ contribute to the function of the destruction complex (Azzolin et al., 2014) (Figure 3).”
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Besides manchanotransduction, Wnt ligand-linked collagen culture is sufficient to induce YAP/TAZ activation and support cellular reprogramming [144], in accord with previous discovery of Wnt-YAP/TAZ pathway [145, 146].”