Rab27a and Rab27b control different steps of the exosome secretion pathway

By M. Ostrowski, N. Carmo, S. Krumeich, I. Fanget, G. Raposo, A. Savina, Catarina F Moita, Kristine Schauer, Alistair N. Hume, Rui P. Freitas and 10 more. Nature Cell Biology, 2010

2,524 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9347e205d8942632788392d997a01b3e09f4ffe6

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Citations in the corpus

Exosomes and other extracellular vesicles in host–pathogen interactions (2014, neutral): “Rab27a and Rab27b were also shown to have different, but sometimes redundant, roles in MVB biogenesis, with Rab27a more implicated in mediating MVB docking to the plasma membrane [49].”
Cancer exosomes trigger fibroblast to myofibroblast differentiation. (2010, positive): “Recently, Rab GTPases, Rab27a and Rab27b, have been shown to play important roles in regulating exosome secretion (35).”
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources (2016, background): “Enrichment of Rab proteins in EVs, a protein family indicated in exosomal biogenesis (45), showed marked source cell dependency, suggesting that protein sorting mechanisms into EVs may depend on source cell type.”
Interaction and uptake of exosomes by ovarian cancer cells (2011, background): “Exosomes are released by multivesicular bodies fusion with the plasma membrane and the mechanism appears to involve Rab27A and Rab27B [10].”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Simultaneously, our small hairpin RNA (shRNA)-based screen in HeLa cells expressing MHC class II molecules showed that silencing of RAB2B, RAB5A, RAB9A, and most efficiently RAB27A and RAB27B decreased secretion of exosomes bearing CD63, CD81, and MHC class II (Ostrowski et al. 2010).”
BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. (2013, neutral): “Exosomes were isolated from primary BM-MSC conditioned medium obtained from either patients with MM or healthy individuals, as described previously (18, 22, 23).”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “RAB27A RNA interference in melanoma cells was shown to decrease exosome production [63], whereas in HeLa cells, MVB size was strongly increased upon RAB27A RNA interference and redistribution to the perinuclear region occurred upon RAB27B silencing [61].”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “Importantly, the mechanisms of MVB trafficking and fusion with the cell membrane are regulated by several Rab guanosine triphosphatase (GTPase) proteins and are coordinated with cytoskeletal and molecular motor activities [44, 45].”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Studies from Thery and colleagues demonstrated that a number of Rab family proteins, including Rab27a and Rab27b, act as key regulators of the exosome secretion pathway [41].”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “In this regard, Rab27a GTPase has been demonstrated to modulate exosome secretion (62) and the vesicular secretion of some conventional markers of exosomes such as the tetraspanin CD63, but does not affect the secretion of tetraspanin CD9.”
Tumor-derived exosomes and their role in cancer progression (2016, background): “The Rap GTPase proteins, especially Rab27a and Rab27b, controlling the secretory pathways are strongly implicated in exosome release [30, 31].”
Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “Importantly, recent reports have documented key processes involved in exosome release andhave identified similarities in topology andmechanisms to retroviral budding (15, 16).”
The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “130).”