BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

By A. Roccaro, A. Sacco, P. Maiso, Abdel Kareem Azab, Y. Tai, M. Reagan, F. Azab, L. Flores, F. Campigotto, E. Weller and 3 more. Journal of Clinical Investigation, 2013

760 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/defdab25fed905fd85e1be2c678723743075864e

How researchers see this paper

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In Molecular Biology

1. C. Gregory
2. Fazlul H. Sarkar
3. Asfar S. Azmi
4. Bin Bao
5. Jeffrey L Spees
6. R. Lee

In Oncology

1. Fazlul H. Sarkar
2. Asfar S. Azmi
3. Bin Bao

Citations in the corpus

• Exosomes in cancer: small particle, big player (2015, background): “IL-6, CCL2, fibronectin Multiple myeloma (MM) BM-MSCs MM cells Promotes tumor cell growth [29]”
• Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro (2015, methodology): “FBS used in culture media for exosome isolation was precleared by ultracentrifugation in Beckman pollyallomer tubes (Beckman Coulter, Brea, CA) using the Optima L-XP preparative ultracentrifuge (Beckman Coulter) at 100,000 g for 3 h at 4 C as described by others [24].”
• New horizons in tumor microenvironment biology: challenges and opportunities (2015, positive): “As supporting evidence, several studies demonstrated that exosomes derived from BM-MSCs can induce progenitor cells to undergo mesenchymal-to-epithelial transition (MET), indicating active message delivery between cancer cells and the bone marrow TME [72,73].”
• Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma (2015, neutral): “loma, and bladder tumors [31–34].”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “For example, MSCs isolated from various tissues differ in terms of exosome content [184, 185] and MSCs from bone marrow with multiple myeloma were reported to differ in miRNA content relative to MSCs from control bone marrow [183].”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “showed that exosomes released from bone marrow derived mesenchymal cells (BM-EMT cells) can promote multiple myeloma (MM) formation in an animal model system [174].”