Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

By D. Mucida, Yunji Park, Gisen Kim, O. Turovskaya, Iain Scott, M. Kronenberg, Hilde Cheroutre. Science, 2007

2,145 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/933df81b9f93e19e5e10d87ffa53cec38542a410

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Regulatory T cells and immune tolerance. (2008, background): “In the presence of TGF-β, retinoic acid facilitates the differentiation of naive T cells to Foxp3 + Tregs (Benson et al., 2007; Mucida et al., 2007; Sun et al., 2007; Coombes et al., 2007).”
Plasticity of CD4+ T cell lineage differentiation. (2009, background): “In addition, several recent studies have implicated RA-producing CD103+ DC in the gut as inducers of Foxp3 expression (Mucida et al., 2007; Coombes et al., 2007; Sun et al., 2007).”
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. (2008, background): “Recently, all-trans retinoic acid (RA) was shown to inhibit the induction of proinflammatory Th17 cells but to promote anti-inflammatory Treg cell differentiation (Mucida et al., 2007).”
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells (2015, background): “This role contrasts with the accepted dichotomy between FoxP3 and Rorγ, a notion stemming mainly from their antagonism in vitro (14, 26-28), perhaps overinterpreted.”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “More recent studies showed that retinoic acid is a critical factor in controlling the balance between Th17 and Treg cells [Coombes et al., 2007; Mucida et al., 2007; Sun et al., 2007].”
Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “The vitamin A metabolite retinoic acid (RA), produced by many types of cells outside lymphoid organs—including nerve cells (38), dendritic cells (DCs) (39), and stromal cells (40)—favors the maturation of ILC3s at the expense of ILC2s (41) and is required for the full maturation of ILC3s in the fetu”
Tolerogenic dendritic cells (2016, background): “In vitro and in vivo studies demonstrated that TGFβ and RA produced by CD103 DCs in the lamina propria, but not in the spleen, mediate the differentiation of FoxP3 pTreg cells, which is abrogated by treatment with a retinoic acid receptor (RAR) antagonist [5, 49].”
IL-17 and Th17 Cells. (2009, background): “The data of others and our own group suggest that in an inflammatory setting, retinoic acid inhibits the generation of Th17 cells rather than enhancing de novo generation of Tregs (70, 78).”
Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, positive): “Vitamin A can modulate the function and development of many immune cell types, including T cells (Iwata et al., 2004; Mucida et al., 2007), B cells (Mora et al.”
Development and maintenance of regulatory T cells. (2013, background): “…molecules, such as TGF-b, retinoic acids, rapamycin, and sphingosine 1-phosphate receptor agonist FTY720 (Battaglia et al., 2006; Hill et al., 2008; Mucida et al., 2007; Zhou et al., 2009a), and that several signaling pathways, including those of NFAT, Smad3, and the Nr4a family, are critical for…”
Regulatory T cells in tumor immunity (2010, background): “which is dependent on TGF-b and retinoic acid, a vitamin A metabolite.(16,17) Additionally, tumor cells may stimulate immature myeloid DCs to secrete TGF-b and contribute to”
Vitamin effects on the immune system: vitamins A and D take centre stage (2008, background): “, it was recently demonstrated by several groups that this process can be significantly enhanced by retinoic aci”