Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

By Ann Cassidy-Stone, J. Chipuk, Elena Ingerman, Cheng Song, C. Yoo, T. Kuwana, M. J. Kurth, Jared T Shaw, Jenny E. Hinshaw, Douglas R. Green and 1 more. Developmental Cell, 2008

1,159 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/92c5ca3c35a5b2ca911b02823b22f0f6e44f3ead

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Molecular Biology

Citations in the corpus

A hyperfused mitochondrial state achieved at G1–S regulates cyclin E buildup and entry into S phase (2009, positive): “Mitochondria were induced to become hyperfused through treatment with mdivi-1, a drug that tubulates mitochondria by specifically inhibiting the mitochondrial fission protein, DRP1 (19).”
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals (2017, positive): “Further, treatment with mdivi-1, an inhibitor of the dynamin GTPase DRP1 that blocks mitochondrial division (Cassidy-Stone et al., 2008), also activated the ATF4 pathway in a time-dependent way (Fig.”
Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics (2011, positive): “In some reports, inhibition of mitochondrial fission or stimulation of fusion, significantly delayed apoptosis (Cassidy-Stone et al., 2008; Frank et al., 2001; Germain et al., 2005; Merrill et al., 2011).”
Mechanisms of mitochondrial fission and fusion. (2013, neutral): “2006), but there are also more selective drugs, like Mdivi-1, which only inhibit Drp1 homologs (Cassidy-Stone et al. 2008).”
Mitochondrial dynamics and apoptosis. (2008, positive): “Most recently, an inhibitor of Dnm1, called mdivi-1, identified using yeast screens of chemical libraries, has been found to block mitochondrial division in yeast and mammalian cells (Cassidy-Stone et al. 2008).”
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, positive): “Mdivi-1 Inhibiting the activity of Drp1 Anti-inflammation, anti-oxidative stress, anti-hypertension Low specificity, protecting cells [200]”
The BCL-2 Family Reunion (2010, positive): “Indeed, loss of DRP-1 or Mff function by RNAi, a dominant-negative DRP1, or pharmacological inhibition of DRP-1 delays MOMP, mitochondrial fragmentation, and apoptosis (Cassidy-Stone et al., 2008; Frank et al., 2001; Gandre-Babbe and van der Bliek, 2008; Lee et al., 2004).”
Mitochondria and cell death: outer membrane permeabilization and beyond (2010, positive): “Pharmacological inhibitors of DRP1 block MOMP in vitro , a setting in which mitochondrial fission does not occur, thereby implying that DRP1 contributes to BAX- or BAK-induced MOMP independently of mitochondrial fissio”