A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.
By S. Paglin, T. Hollister, T. Delohery, Nadia Hackett, M. McMahill, E. Sphicas, D. Domingo, J. Yahalom. Cancer Research, 2001
1,041 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/929eff9f68afc573651abd360107199d30d5e70b
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Citations in the corpus
- Regulation and role of autophagy in mammalian cells. (2004, background): “Although autophagy is reduced in cancer cells compared to their normal counterparts, stimulation of autophagy in cancer cells was observed in response to anti-cancer treatments (Bursch et al., 2000; Inbal, Bialik, Sabanay, Shani, & Kimchi, 2002; Paglin et al., 2001).”
- Inhibition of Macroautophagy Triggers Apoptosis (2005, background): “Finally, a series of bona fide apoptosis inducers can trigger type 2 cell death in some cell types (31, 55, 56).”
- Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells (2004, methodology): “Once cancer cells are exposed to radiation or chemotherapeutic agents, a high rate of autophagy is observed in cancer cells.(15,36) To adapt to adverse conditions induced by cancer therapy, cancer cells trigger reversible autophagic process that sequesters and degrades unnecessary molecules for thei”
- Growth factor regulation of autophagy and cell survival in the absence of apoptosis. (2005, background): “Elimination of extracellular factors on which cells depend to maintain anapleurotictherapy drugs (Daido et al., 2004; Kanzawa et al., 2004; Paglin et al., 2001; Talloczy et al., 2002).”
- Oxidative Stress and Autophagy (2006, unknown): “Likewise, blockage of macroautophagy in some types of cancer cells increases their susceptibility to irradiation (61), suggesting that they may use macroautophagy to defend themselves against the irradiating insult.”