Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

By Petti T. Pang, Henry K Teng, E. Zaitsev, Newton T Woo, K. Sakata, Shushuang Zhen, K. Teng, W. Yung, B. Hempstead, B. Lu. Science, 2004

1,169 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/923ddd1fd7d7694f680ce8cd240aeec84b8e0e1a

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Citations in the corpus

New insights in the biology of BDNF synthesis and release: implications in CNS function (2009, positive): “However, recent observations of proBDNF secretion and its conversion to mBDNF in vitro by plasmin and matrix metalloproteases suggest that proBDNF may be biologically active (Pang et al., 2004), although the efficiency of intracellular cleavage is controversial (Matsumoto et al.”
X-linked mental retardation (2005, background): “Specific targets of MeCP2 include the brain-derived neurotrophic factor (BDNF) and the Hairy2a gene, which are important for long-term synaptic plasticity, learning and memor”
Dendritic protein synthesis, synaptic plasticity, and memory. (2006, background): “…late-phase LTP (Kang and Schuman, 1996) and also maintains late-phase LTP in the presence of protein-synthesis inhibitors, implying that new synthesis of BDNF and associated maturation enzymes can sustain changes in synaptic strength (Pang et al., 2004; see also, Kang et al., 1997).”
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, methodology): “Harvested media were supplemented with proteinase inhibitors and immunoprecipitated with agarose-conjugated anti-proBDNF antiserum (Pang et al., 2004) at 4°C overnight.”
The Influence of Exercise on Cognitive Abilities (2013, neutral): “Based on the described effects of tPA for regulation of LTP and memory formation (133, 134), it is likely that the”
Role of matrix metalloproteinases in delayed cortical responses after stroke (2006, background): “MMPs can also process growth factors into biologically active form”
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, background): “Recently, extracellular cleavage of proBDNF has been shown to be crucial for the expression of late-phase LTP in the hippocampu”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, neutral): “(Tyler et al, 2002; Pang et al, 2004; Lu and Woo, 2006).”
BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. (2005, background): “) If a BDNF signaling loop exists, how is it initiated and terminated? Does sustained release involve re-exocytosis of endocytosed BDNF or release from previously loaded secretory granules? Recent work in region CA1 provides compelling evidence for release of pro-BDNF during LTP (Pang et al., 2004).”
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020, background): “Extracellular cleavage of proBDNF is determined by plasmin [71] and matrix metalloproteases 2 and 9 (MMP2 and MMP9) [72,73].”
Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis (2014, neutral): “We searched plasmin substrate databases (MEROPS and CutDB) for proteins whose cleavage might affect brain metastasis (Bajou et al., 2008; Chen and Strickland, 1997; Nayeem et al., 1999; Pang et al., 2004).”