Role of matrix metalloproteinases in delayed cortical responses after stroke

By Bing-Qiao Zhao, Sophia Wang, H. Kim, Hannah Storrie, Bruce R. Rosen, David J. Mooney, Xiaoying Wang, Eng H. Lo. Nature Medicine, 2006

708 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/7654016e52863196c70d974244f8902382da1850

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Berislav Zlokovic
2. Jian Wang
3. B. Bauer
4. Francis G. Spinale
5. A. Hartz
6. S. Doré
7. R. Rempe

In Hematology

1. Berislav Zlokovic
2. Jian Wang
3. S. Doré

In Oncology

1. Berislav Zlokovic
2. Jian Wang
3. B. Bauer
4. Francis G. Spinale
5. A. Hartz
6. S. Doré
7. R. Rempe

Citations in the corpus

• The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, positive): “Since MMPs also participate in regulating neurogenesis and angiogenesis, as for example during a repair phase after stroke (Zhao et al., 2006), more work is needed to clarify the therapeutic potential of MMP inhibition in different brain pathologies.”
• The inflammatory response in stroke. (2007, background): “This was also associated with reduced VEGF signaling resulting from MMP inhibition (Zhao et al., 2006).”
• A new penumbra: transitioning from injury into repair after stroke (2008, background): “Although MMPs disrupt neurovascular matrix and cause injury during acute stroke, they can promote neurovascular remodeling in peri-infarct cortex during the delayed stages of stroke recover”
• Inflammation after Intracerebral Hemorrhage (2007, background): “Therefore, instead of MMP inhibitor therapies for acute ICH, strategies that focus on modulating the activity of MMPs may be considered for improving recovery and enhancing long-term functional outcome, as suggested in ischemic stroke (Zhao et al, 2006a).”
• Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “Inhibiting MMPs with FN-439 or BB-94 in a rat stroke model for one week even aggravated ischemic brain injury and seemed to halt functional recovery.(191) Even though MMP inhibition seems promising in animal models, this has not or only partially been demonstrated in clinical studies.”
• Blood-brain barrier pathophysiology in traumatic brain injury (2011, background): “While these observations, collectively, suggest that MMPs could represent the potential targets for pharmacological intervention in TBI, it should be emphasized that MMPs may also play an important role in the neuronal repair processes at the later stage postinjury, and the inhibition of their activ”
• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. (2007, background): “Other growth factors, such as the release of active insulin-like growth factor, can be mediated by several MMP types (256, 276, 299, 508, 541).”