Relevance of Breast Cancer Cell Lines as Models for Breast Tumours: An Update

By M. Lacroix, G. Leclercq. Breast Cancer Research and Treatment, 2004

834 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/91c7dd12ff84548a6638b4ecb5afff90caf692d0

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Citations in the corpus

Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping (2017, methodology): “MDAMB361 + +/- + WT LB MDA RPMI, DMEM AC L [1, 5, 6, 8, 10]”
Choosing the right cell line for breast cancer research (2011, background): “A comprehensive evaluation of breast cancer cell lines by Lacroix and Leclercq, conducted before molecular profi ling of breast cancer was widespread, concluded that while breast cancer cell lines have advanced our understanding of breast cancer biology, gaps still remained in terms of how represent”
Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery (2009, background): “Breast cancer cell lines have been used widely to investigate breast cancer pathobiology, and to screen and characterize new therapeutics [6,7].”
The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression (2007, background): “AU565, BT-474, HCC1569, SK-BR-3, MDA-MB-361, MDA-MB-453, and UACC-812 have been reported to have amplified this gene (Lacroix and Leclercq, 2004 and references therein; Neve et al., 2006).”
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 (2008, background): “In addition, the invasiveness of commonly used breast cancer cell lines is often correlated with their mesenchymal stat”
Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “As eloquently stated by Lappin and colleagues (Lappin et al., 2002) ‘‘The poetic rhythm of the developmental programme 376 H U G O E T A L . does not always appear to resonate with the same harmony in the adult form’’ and EMT in disease is no exception.”
Investigating the optimal size of anticancer nanomedicine (2014, background): “MCF-7 is an estrogendependent, noninvasive human breast cancer cell line that is extensively studied as a xenograft model for ER/HER2 breast cancer (35).”
Modelling breast cancer: one size does not fit all (2007, background): “Breast cancer cell lines Breast cancer cell lines have been the most widely used models to investigate how proliferation, apoptosis and migration become deregulated during the progression of breast cance”
The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity (2007, background): “…of epithelial differentiation To identify ZEB1 target genes in cancer cells we examined the genome-wide transcriptional repertoire of ZEB1 in the highly metastatic MDA-MB-231 breast cancer cell line, which has been widely used as an invasion and metastasis cell model (Lacroix and Leclercq, 2004).”
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy (2008, background): “231 and MCF7), primary breast cancers (SUM149 and SUM159), primary tumor recurrences (SUM225), and even xenografted metastatic nodules (SUM1315) [8,9].”
GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer (2009, background): “In the T47D, MCF-7 and Hs578T cell lines, the level of GAS5 transcripts is 10-fold higher than those in MDA-MB231, the most metastatic cell line capable of producing lung and lymph metastasis in a high proportion in nude mice (Lacroix and Leclercq, 2004).”