The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression

By P. Kenny, Genee Y. Lee, Connie Myers, R. Neve, J. Semeiks, P. Spellman, Katrin Lorenz, Eva H. Lee, M. Barcellos-Hoff, O. Petersen and 2 more. Molecular Oncology, 2007

1,078 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4fe0466e44294ffa56b70edca76d0e706858e4ec

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In Molecular Biology

1. X. Chen
2. Charles M. Perou
3. Jeffrey M. Rosen
4. R. Kaufman

Citations in the corpus

• Deconstructing the molecular portraits of breast cancer (2010, background): “Interestingly, the Luminal, Basal-A and Basal-B molecular groups are also maintained during 3D cell culture (Kenny et al., 2007).”
• Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. (2011, methodology): “Patients were all treated with surgery without adjuvant therapy GSE-2603A USA Primary breast cancers surgically resected 99 ER, PR 32 (32) 0.”
• Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors (2014, methodology): “Figure 2 shows the four distinct structures of 3D spheroids formed by breast cancer cell lines.(35) The round-type spheroid exhibits strong cell–cell adhesion, and the nuclei are regularly organized around the center of the colony.”
• Triple Negative Breast Cancer Cell Lines: One Tool in the Search for Better Treatment of Triple Negative Breast Cancer (2010, background): “For example, the basal B TNBC cell lines MDA-MB-231 and HS578t grow with a stellate pattern while the basal A TNBC cell line MDA-MB-468 TNBC grows with a grape cluster like pattern [80].”
• Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping (2017, neutral): “, the place where the cell line is created [12, 14, 15, 49, 60, 66-70].”
• Modelling breast cancer: one size does not fit all (2007, background): “Recently, to determine whether gene expression, like morphology, is more faithfully recapitulated in breast cancer cell lines when grown in 3D reconstituted basement membrane (rBM) cultures, the molecular profiles of 25 breast cancer cell lines cultured in 2D versus 3D conditions were compare”
• Choosing the right cell line for breast cancer research (2011, background): “In contrast, cell lines grown in three-dimensional culture showed four diff erent morphologies: round, mass, grape-like and stellate [38].”
• Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway (2012, neutral): “MDA-468 cells exhibit a less invasive but highly disorganized appearance and have been classified as ‘‘grape-like’’ (Kenny et al., 2007).”
• Three-dimensional culture models of normal and malignant breast epithelial cells (2007, methodology): “For instance, we recently used the 3D on-top assay to analyze the correlations between colony morphology and gene expression in a large panel of breast cancer cell line”